SELANK 10mg
$35.00
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Buy Selank 10mg – Tuftsin-Derived GABAergic Research Peptide
Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as a synthetic analog of tuftsin – a naturally occurring tetrapeptide (Thr-Lys-Pro-Arg) derived from the heavy chain of immunoglobulin G. The Pro-Gly-Pro C-terminal extension (the same stabilizing motif used in Semax) was added to resist prolyl endopeptidase degradation. Selank has the most clinically developed research base of any anxiolytic peptide – having completed Phase 3 clinical trials in Russia for generalized anxiety disorder.
In 10mg lyophilized format, independently tested to greater than 99% purity. All products for laboratory research use only.
Primary Research Mechanism – GABAergic Modulation
Selank’s primary studied mechanism is positive allosteric modulation of GABA(A) receptors – an anxiolytic mechanism distinct from benzodiazepine binding site interactions. Unlike classical GABA(A) modulators, Selank does not produce receptor downregulation or tolerance development in published research models, making it a mechanistically distinct research tool for studying GABAergic pathways.
Primary: Positive allosteric modulation of GABA(A) receptors – anxiolytic pathway
Enkephalin stability: Inhibits enzymes (enkephalinase) that degrade endogenous enkephalins – potentiates opioid pathway
Serotonergic: Modulates serotonin uptake and neurotransmitter balance in research models
Immunomodulation: Tuftsin origin confers cytokine modulation properties (IL-6, IL-8 pathway)
No tolerance/dependence: Published research shows no receptor downregulation unlike benzodiazepines
Product Specifications
| Compound | Selank (Thr-Lys-Pro-Arg-Pro-Gly-Pro) |
| Sequence | TKPRPGP (Thr-Lys-Pro-Arg-Pro-Gly-Pro) |
| Also Known As | TP-7, Selanc, Heptapeptide tuftsin analog |
| Origin | Tuftsin (Thr-Lys-Pro-Arg) + Pro-Gly-Pro stabilizing extension |
| CAS Number | 129954-34-3 |
| Molecular Formula | C33H57N11O9 |
| Molecular Weight | 751.87 g/mol |
| Amino Acids | 7 (heptapeptide) |
| Form | Lyophilized powder - white to off-white, water-soluble |
| Purity | >99% HPLC Verified - Batch COA Available |
| Available Size | 10mg |
| Clinical Background | Completed Phase 3 trials in Russia for GAD (generalized anxiety disorder) |
| Storage | Lyophilized: -20°C | Reconstituted: 2-8°C, use within 28 days |
| Reconstitution | Bacteriostatic Water (BAC Water) |
| Intended Use | Research Use Only (RUO) |
Frequently Ask Questions
What is tuftsin and why is Selank based on it?
Tuftsin (Thr-Lys-Pro-Arg) is a naturally occurring tetrapeptide fragment derived from the Fc region of immunoglobulin G (IgG). It was originally studied for its immunostimulatory properties. The Institute of Molecular Genetics researchers extended tuftsin with a Pro-Gly-Pro tripeptide tail to create Selank - this extension improves enzymatic stability while the core tuftsin sequence contributes to the anxiolytic and immunomodulatory activity profile.
Is Selank approved for human use?
No. Selank is sold strictly for laboratory and controlled scientific research purposes only (RUO). Not approved by the FDA for human or veterinary use in the United States. In Russia, Selank has been studied in clinical settings - our product is US research-grade material only.
