VIP 10mg
$40.00
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Buy VIP 10mg—Vasoactive Intestinal Peptide Research
VIP (Vasoactive Intestinal Peptide) is an endogenous 28-amino acid neuropeptide expressed across the central nervous system, peripheral nervous system, gastrointestinal tract, and immune tissue. Originally named for its vasodilatory properties, VIP is now recognized as a multi-system signaling molecule with roles in neuroprotection, circadian rhythm regulation, immune modulation, and neuroendocrine signaling. It signals primarily through two G-protein coupled receptors: VPAC1 (widely distributed) and VPAC2 (expressed in brain, lung, and T-cells specifically).
In 10mg lyophilized research format, independently tested to greater than 99% purity. All products for laboratory research use only.
Research Mechanisms
VPAC1/VPAC2 Receptor Biology
VIP research centers on its two receptor systems: VPAC1 (high-affinity, widely expressed—brain, lung, GI, immune) and VPAC2 (more restricted—brain regions, T-cells, reproductive tissue). Understanding receptor-specific signaling is a primary research application—compounds selective for VPAC1 vs VPAC2 produce distinct downstream effects, making full-length VIP a useful reference compound for comparative receptor pharmacology.
VPAC1 signaling: cAMP pathway activation, neurotrophin expression modulation
VPAC2 signaling: Circadian rhythm regulation through suprachiasmatic nucleus (SCN)
Immune modulation: Anti-inflammatory cytokine production modulation, T-cell differentiation
Neuroprotection: Studied for anti-apoptotic signaling in CNS research models
Circadian: VIP-VPAC2 axis is a critical component of SCN circadian pacemaker function
Product Specifications
| Compound | VIP (Vasoactive Intestinal Peptide) |
| Type | Endogenous 28-amino acid neuropeptide - synthetic research grade |
| CAS Number | 37221-79-7 |
| Molecular Formula | C147H237N43O43S |
| Molecular Weight | 3,325.8 g/mol |
| Amino Acids | 28 |
| Receptors | VPAC1 (VIPR1), VPAC2 (VIPR2) |
| Form | Lyophilized powder |
| Purity | >99% HPLC Verified - Batch COA Available |
| Available Size | 10mg |
| Storage | Lyophilized: -20°C | Reconstituted: 2-8°C, use within 28 days |
| Reconstitution | Bacteriostatic Water (BAC Water) |
| Intended Use | Research Use Only (RUO) |
Frequently Ask Questions
Why is VIP categorized under Cognitive & Longevity?
VIP's cognitive research relevance stems from its roles in neuroprotective signaling and circadian rhythm regulation - both areas with significant aging biology implications. VPAC2-mediated VIP signaling in the suprachiasmatic nucleus (SCN) is a key component of circadian pacemaker function, making VIP relevant to circadian biology research alongside longevity and cognitive research protocols.
Is VIP approved for human use?
No. Our research-grade VIP is sold strictly for laboratory and controlled scientific research purposes only (RUO). Not approved for human or veterinary use.
