MOTS-C 40mg
$75.00
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Buy MOTS-C 40mg – Mitochondrial-Derived Longevity Research Peptide
MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA Type-C) is a 16-amino acid peptide encoded in the mitochondrial genome – specifically in the 12S ribosomal RNA region. Identified in 2015 by Chang Lee and colleagues (published in Cell Metabolism), MOTS-C is one of the few peptides encoded outside the nuclear genome, making it a unique Mitochondrial-Derived Peptide (MDP). Unlike virtually all other research peptides, MOTS-C is a product of mitochondrial gene expression – not nuclear genome translation.
In July 2026, MOTS-C (listed as MOTs-C) was included in the FDA Pharmacy Compounding Advisory Committee review session alongside BPC-157, KPV, TB-500, DSIP, Semax, and Epitalon. Available in 40mg lyophilized format, independently tested to greater than 99% purity. All products for laboratory research use only.
Unique Research Characteristics – Mitochondrial Genome Origin
MOTS-C’s most distinctive research characteristic is its origin in the mitochondrial genome – and its function as a retrograde signaling molecule traveling from the mitochondria to the nucleus. This inter-organelle communication role is mechanistically unique among all research peptides in the Midnight Sun catalog.
Genome origin: Mitochondrial DNA (12S rRNA region) – not nuclear genome – unique among research peptides
Retrograde signaling: Travels from mitochondria, nucleus, activates nuclear stress response pathways
AMPK activation: Studied for AMPK pathway modulation – central metabolic energy-sensing kinase
Metabolic homeostasis: Insulin sensitivity and glucose metabolism pathway research in animal models
Exercise mimetic research: Published studies examining exercise-related metabolic adaptation signaling
Aging biology: Mitochondrial-to-nuclear communication is a key hallmark of aging – MOTS-C as research tool
Product Specifications
| Compound | MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA Type-C) |
| Also Known As | MOTs-C, MOTS-c |
| Origin | Mitochondrial genome-encoded (12S rRNA region) - 16 amino acid peptide |
| Type | Mitochondrial-Derived Peptide (MDP) |
| CAS Number | 1627580-64-6 |
| Molecular Formula | C64H102N22O18 |
| Molecular Weight | 1,525 g/mol (approximate) |
| Amino Acids | 16 |
| Sequence | MRWQEMGYIFYPRKLR |
| Form | Lyophilized powder |
| Purity | >99% HPLC Verified - Batch COA Available |
| Available Size | 40mg |
| Discovery | First described 2015 - Lee et al., Cell Metabolism |
| Regulatory Note | FDA PCAC reviewed as MOTs-C - July 2026 session |
| Storage | Lyophilized: -20°C | Reconstituted: 2-8°C, use within 28 days |
| Reconstitution | Bacteriostatic Water (BAC Water) |
| Intended Use | Research Use Only (RUO) |
Frequently Ask Questions
