KISSPEPTIN 10mg
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Buy Kisspeptin-10 10mg — GPR54 Receptor Research Peptide
Kisspeptin-10 (KP-10, Metastin-10) is a synthetic 10-amino acid decapeptide derived from the KISS1 gene – specifically representing the C-terminal decapeptide fragment (amino acids 112-121) that constitutes the minimal bioactive sequence for GPR54 receptor activation. The KISS1 gene encodes a family of kisspeptin peptides of varying lengths (54, 14, 13, and 10 amino acids), all of which share this same C-terminal decapeptide sequence. Kisspeptin-10 is selected over longer isoforms for research use because of its superior blood-brain barrier penetration and equivalent GPR54 agonist efficacy in published research models.
Originally named “metastin” when first discovered as a metastasis-suppressor gene product, KISS1 was subsequently identified as the central activator of the hypothalamic-pituitary-gonadal (HPG) axis – a discovery that fundamentally changed our understanding of reproductive endocrinology. In 10mg lyophilized format, independently tested to greater than 99% purity. All products for laboratory research use only.
GPR54 Receptor & HPG Axis Research
The GPR54 Receptor (KISS1R)
GPR54 (also called KISS1R or Kisspeptin receptor) is a Gq-coupled seven-transmembrane receptor expressed on GnRH (gonadotropin-releasing hormone) neurons in the hypothalamus, as well as in the pituitary, gonads, placenta, and brain. Kisspeptin-10 binding to GPR54 triggers Gq/11-mediated phospholipase C activation, leading to IP3-mediated calcium release and PKC activation – the intracellular signaling cascade that ultimately triggers GnRH release.
HPG Axis Signal Cascade
Kisspeptin-10,GPR54 activation,GnRH pulse release from hypothalamic neurons,pituitary LH and FSH secretion,gonadal sex hormone production. This makes Kisspeptin-10 the pharmacological key to the entire reproductive hormone cascade – a single compound that can trigger the complete HPG axis signaling sequence in research models. Published research has documented dose-dependent LH and FSH increases following Kisspeptin-10 in rodent, primate, and human research models.
Why Kisspeptin-10 vs Longer Isoforms
The C-terminal amide group on Kisspeptin-10 is critical for GPR54 binding – and this fragment, being the smallest bioactive form, offers better penetration characteristics in research models compared to kisspeptin-54 (the full precursor). In published research comparing kisspeptin isoforms, KP-10 consistently demonstrated equivalent or superior GPR54 activation efficacy with better tissue distribution in CNS research models.
Research Applications Beyond Reproduction
GPR54 receptor pharmacology – binding kinetics, G-protein coupling, downstream signaling
HPG axis research – GnRH pulse dynamics, LH/FSH secretion studies, gonadotropin regulation
Cardiovascular signaling: GPR54 is expressed in vascular tissue – studied for vasodilatory mechanisms
Metabolic endocrine interactions: Kisspeptin neurons interact with energy sensing pathways
Cancer research: KISS1 was originally identified as a metastasis suppressor gene – oncology research context
Product Specifications
| Compound | Kisspeptin-10 (KP-10, Metastin-10) |
| Also Known As | KP-10, Metastin-10, KISS1(112-121) |
| Gene | KISS1 gene product - C-terminal decapeptide fragment |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (10 amino acids) |
| Type | Synthetic decapeptide - shortest bioactive kisspeptin fragment |
| Receptor | GPR54 (KISS1R) - G-protein coupled receptor |
| CAS Number | 375672-12-7 |
| Molecular Formula | C54H65N13O11 (approximate) |
| Molecular Weight | ~1,161 g/mol (approximate) |
| Form | Lyophilized powder - white, water-soluble |
| Purity | >99% HPLC Verified - Batch COA Available |
| Available Size | 10mg |
| Research Advantage | Improved BBB penetration vs kisspeptin-54 (54aa) and kisspeptin-13 (13aa) |
| Storage | Lyophilized: -20°C | Reconstituted: 2-8°C, use within 28 days |
| Reconstitution | Bacteriostatic Water (BAC Water) |
| Intended Use | Research Use Only (RUO) |
Frequently Ask Questions
What is the difference between Kisspeptin-10, Kisspeptin-13, and Kisspeptin-54?
All three are products of the same KISS1 gene. Kisspeptin-54 is the full precursor peptide (54 amino acids). Kisspeptin-13 is a 13-amino acid C-terminal fragment. Kisspeptin-10 is the shortest bioactive 10-amino acid C-terminal fragment. All three share the same C-terminal 10-amino acid sequence (YNWNSFGLRF-NH2) that binds GPR54. Kisspeptin-10 is preferred for research because it retains full GPR54 agonist activity in a smaller, more penetrant format. The amidated C-terminus (-Phe-NH2) is essential for receptor binding.
Why is Kisspeptin-10 called "Metastin-10"?
Kisspeptin/KISS1 was originally identified in 1996 as a melanoma metastasis suppressor gene product - hence the name "metastin" (metastasis + statin). The KISS1 gene was found to suppress metastatic potential of human melanoma cells when expressed. Only later was the same compound identified as the central GPR54 ligand controlling GnRH and reproductive hormone signaling. Both "Kisspeptin-10" and "Metastin-10" refer to the same compound (CAS 375672-12-7).
Is Kisspeptin-10 approved for human use?
No. Kisspeptin-10 is sold strictly for laboratory and controlled scientific research purposes only (RUO). Not approved for human or veterinary use.
