KISSPEPTIN 10mg
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Buy Kisspeptin-10 10mg — Research-Grade Peptide
Kisspeptin-10 is a synthetic peptide supplied as a research-grade compound for controlled laboratory and analytical research. It is provided for research use only and is not intended for human or veterinary use.
Originally named “metastin” when first discovered as a metastasis-suppressor gene product, KISS1 was subsequently identified as the central activator of the hypothalamic-pituitary-gonadal (HPG) axis – a discovery that fundamentally changed our understanding of reproductive endocrinology. In 10mg lyophilized format, independently tested to greater than 99% purity. All products for laboratory research use only.
Research Compound Overview
The GPR54 Receptor (KISS1R)
GPR54 (also called KISS1R or Kisspeptin receptor) is a Gq-coupled seven-transmembrane receptor expressed on GnRH (gonadotropin-releasing hormone) neurons in the hypothalamus, as well as in the pituitary, gonads, placenta, and brain. Kisspeptin-10 binding to GPR54 triggers Gq/11-mediated phospholipase C activation, leading to IP3-mediated calcium release and PKC activation – the intracellular signaling cascade that ultimately triggers GnRH release.
HPG Axis Signal Cascade
Kisspeptin-10,GPR54 activation,GnRH pulse release from hypothalamic neurons,pituitary LH and FSH secretion,gonadal sex hormone production. This makes Kisspeptin-10 the pharmacological key to the entire reproductive hormone cascade – a single compound that can trigger the complete HPG axis signaling sequence in research models. Published research has documented dose-dependent LH and FSH increases following Kisspeptin-10 in rodent, primate, and human research models.
Research Applications Beyond Reproduction
GPR54 receptor pharmacology – binding kinetics, G-protein coupling, downstream signaling
HPG axis research – GnRH pulse dynamics, LH/FSH secretion studies, gonadotropin regulation
Cardiovascular signaling: GPR54 is expressed in vascular tissue – studied for vasodilatory mechanisms
Metabolic endocrine interactions: Kisspeptin neurons interact with energy sensing pathways
Cancer research: KISS1 was originally identified as a metastasis suppressor gene – oncology research context
Product Specifications
| Compound | Kisspeptin-10 (KP-10, Metastin-10) |
| Also Known As | KP-10, Metastin-10, KISS1(112-121) |
| Gene | KISS1 gene product - C-terminal decapeptide fragment |
| Sequence | Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 (10 amino acids) |
| Type | Synthetic decapeptide - shortest bioactive kisspeptin fragment |
| Receptor | GPR54 (KISS1R) - G-protein coupled receptor |
| CAS Number | 375672-12-7 |
| Molecular Formula | C54H65N13O11 (approximate) |
| Molecular Weight | ~1,161 g/mol (approximate) |
| Form | Lyophilized powder - white, water-soluble |
| Purity | >99% HPLC Verified - Batch COA Available |
| Available Size | 10mg |
| Storage | Lyophilized: -20°C | Reconstituted: 2-8°C, use within 28 days |
| Reconstitution | Bacteriostatic Water (BAC Water) |
| Intended Use | Research Use Only (RUO) |
Frequently Ask Questions
What is the difference between Kisspeptin-10, Kisspeptin-13, and Kisspeptin-54?
Kisspeptin-10, Kisspeptin-13, and Kisspeptin-54 are related Kisspeptin/KISS1-derived peptide forms that differ in sequence length. Researchers may compare these forms in controlled laboratory studies to investigate differences in molecular characteristics and experimental behavior.
Why is Kisspeptin-10 called "Metastin-10"?
Kisspeptin-10 is also referred to as Metastin-10 in scientific literature. The name is associated with the KISS1/Metastin terminology used in earlier research. Both names refer to the same peptide form.
Is Kisspeptin-10 approved for human use?
No. Kisspeptin-10 is sold strictly for laboratory and controlled scientific research purposes only (RUO). Not approved for human or veterinary use.
