5-AMINO-1MQ 50mg
$45.00
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Buy 5-Amino-1MQ 50mg—NNMT Enzyme Inhibitor Research Compound
5-Amino-1MQ (5-Amino-1-methylquinolinium) is a small-molecule inhibitor of Nicotinamide N-Methyltransferase (NNMT)—an enzyme expressed primarily in adipose tissue and liver that plays a key role in NAD+ metabolism and one-carbon metabolism. By inhibiting NNMT, 5-Amino-1MQ preserves intracellular SAM (S-adenosyl methionine) availability and elevates NAD+ levels in research models—pathways of significant interest in metabolic and aging biology research.
5-Amino-1MQ is available in 50mg research format, independently tested to greater than 99% purity. All products are for laboratory research use only.
Classification & Mechanism
NNMT catalyzes the methylation of nicotinamide using S-adenosyl methionine (SAM) as a methyl donor, producing 1-methylnicotinamide and S-adenosyl homocysteine (SAH). This reaction consumes both SAM and NAD+ precursors, making NNMT a central node in cellular methyl group economy and NAD+ biosynthesis.
5-Amino-1MQ inhibits NNMT by competing with nicotinamide at the substrate binding site. In research models, NNMT inhibition produces several downstream effects: NAD+ level elevation (by reducing nicotinamide consumption), SAM preservation (reducing methyl donor depletion), AMPK pathway activation, and adipocyte differentiation signaling changes. These mechanisms make 5-Amino-1MQ a research tool for studying the intersection of NAD+ metabolism, one-carbon metabolism, and adipose tissue biology.
Target enzyme: NNMT (Nicotinamide N-Methyltransferase)
Mechanism: Competitive inhibition at the nicotinamide substrate binding site
Downstream: NAD+ preservation, SAM conservation, AMPK pathway modulation
Primary research tissue: Adipose tissue and hepatic models
Research Context
NNMT is overexpressed in various metabolic disease states and has been identified as a metabolic master regulator in adipose tissue. Elevated NNMT activity is associated with reduced NAD+ availability and impaired metabolic flexibility. Research with 5-Amino-1MQ investigates how NNMT inhibition affects adipocyte differentiation and lipid metabolism signaling, NAD+ pool restoration in metabolically compromised research models, one-carbon metabolism pathway dynamics, and AMPK/mTOR pathway interactions in energy-sensing research.
Research Applications:
NNMT enzyme kinetics
NAD+ metabolism pathway research
Adipose tissue biology
One-carbon metabolism studies
Metabolic signaling pathway research
Product Specifications
| Compound | 5-Amino-1-methylquinolinium (5-Amino-1MQ) |
| Type | Small molecule NNMT enzyme inhibitor |
| Class | Nicotinamide N-Methyltransferase (NNMT) Inhibitor |
| Molecular Formula | C10H11N2+ (as iodide salt: C10H11IN2) |
| Molecular Weight | ~270.1 g/mol (iodide salt) |
| Form | Lyophilized / crystalline powder |
| Purity | >99% (HPLC Verified - Batch COA Available) |
| Available Size | 50mg |
| Storage | -20°C, protect from moisture and light |
| Reconstitution | DMSO or sterile water (check solubility for your protocol) |
| Intended Use | Research Use Only (RUO) - Not for human or veterinary use |
Frequently Ask Questions
What is NNMT and why is it a research target?
NNMT (Nicotinamide N-Methyltransferase) is an enzyme that methylates nicotinamide, consuming SAM and NAD+ precursors. It is highly expressed in adipose tissue and upregulated in metabolic disease states. Inhibiting NNMT preserves NAD+ availability and SAM pools, making it a research target for studying NAD+ metabolism, adipose tissue biology, and metabolic signaling pathways.
What reconstitution solvent should I use for 5-Amino-1MQ?
5-Amino-1MQ is a small molecule (not a peptide) and may require DMSO for initial dissolution in some protocols. Check your specific research protocol requirements. For in vitro cell culture work, prepare a stock solution in DMSO and dilute in aqueous buffer to desired working concentration. Always verify solubility requirements for your specific assay conditions before reconstitution.
Is 5-Amino-1MQ a peptide?
No. 5-Amino-1MQ is a small molecule compound, not a peptide. It is classified as an NNMT enzyme inhibitor - a synthetic quinolinium compound that inhibits the NNMT enzyme. We include it in our Weight Management research catalog because of its mechanistic relevance to metabolic research alongside our GLP-class peptide compounds.
